Effect of benzoyl taurine dipotassium salt on coagulation, hemostasis and vascular activity in the microvasculature of the brain in violation of cerebral circulation
نویسندگان
چکیده
Cerebral circulation disorders (CCD) are one of the most common causes mortality and disability in population. Improving microcirculation brain tissue is main directions treatment prevention CCD. Aim study was to evaluate effect a new derivative hydroxybenzoic (salicylic) acid on neurological deficit, hemostasis functional state arterial pial vessels prostacyclin-synthetic activity evaluation NOmediated endothelial dysfunction rats under experimental CCD conditions. Material methods. The experiment carried out 50 Wistar rats, which were simulated for by occlusion carotid arteries. Within 7 days after operation, animals received according group: saline, C-60 (N-(3-hydroxybenzoyl)taurine dipotassium salt) acetylsalicylic acid. After treatment, system assessed reaction indomethacin, estimated tests with acetylcholine L-NAME. parameters plasma platelet also studied, behavioral (open field, adhesion test, rotarod, Morris water maze, passive avoidance task) used assess deficits animals. Results. When studying level deficit ischemia course administration test compound, it noted that treated groups, compared control group, there significant increase motor exploratory activity, improvement sensory-motor function coordination movements (p < 0.05). Also, group salicylic derivative, normalization hemostasis, vascular endothelium observed. According results assessing prostacyclin-synthesizing cerebral vessels, follows compound inhibits cyclooxygenase at comparable Conclusions . A acid, salt N-(3-hydroxybenzoyl)taurine, reduces severity improves experiment.
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ژورنال
عنوان ژورنال: Sibirskij nau?nyj medicinskij žurnal
سال: 2022
ISSN: ['2410-2512', '2410-2520']
DOI: https://doi.org/10.18699/ssmj20220507